Could Turmeric be the Most Valuable Nutritional Supplement in Existence? Count its Benefits!

turmeric supplement health benefits

Did you know:

Turmeric may be the most powerful herb and effective nutritional supplement in existence?

There are over 9000 published scientific studies on turmeric, making it arguably the most studied natural supplement?

Curcumin has been found comparable to a range of medications in their effects, including anti-inflammatory, pain relief, heart attack prevention, and anti-depressant drugs?

Curcumin was found consistently outperforms ibuprofen or aspirin for inflammation and pain relief?

Curcumin in turmeric can easily cross the blood-brain barrier giving its great potential in neuro conditions such as memory, cognition, mood, anxiety, depression, headaches, Alzheimer’s and Parkinson’s diseases?

Turmeric supplementation was found to be comparable to aerobic exercise in promoting heart health of older females?

Turmeric supplements can significantly decrease body mass index (BMI), weight, fat and waist and hip circumference?

Black pepper can increase curcumin’s usability in our body by an incredible 2,000%?

Reviewing scientific studies behind our Gold Health Turmeric XTR 28,000 formulation, we are pleased by not at all surprised to find that since the development of the formulation many more studies were done and added to the evidenced-based health benefits of turmeric. Can you believe there are over 20 health benefits in different areas of our body that have been studied of turmeric?

This article endeavours to summarize all currently available research to give a thorough overview of the potential health benefits of turmeric and its value in health maintenance through dietary supplementation and its potential medicinal actions as we continue the studies and research in this field.

Introducing Turmeric and Curcumin

turmeric plant and curcumin

Also called Indian saffron or the golden spice, Turmeric is a traditional Indian spice, that is the root of the Curcuma longa plant (a tall flowering plant) in the ginger family. It has a distinct gold/orange colour. Being the main spice in curry, it gives curry the characteristic yellow colour. Turmeric is widely used in cooking in India, Southeast Asia, and the Middle East. It has been used to treat health concerns such as respiratory conditions, inflammation joint problems, digestive issues, skin conditions and chronic pain since ancient times in these countries. [1]

Having been used as not only a spice but also a medicinal herb in India for thousands of years, turmeric is rapidly attracting attention in more recent scientific research and studies, backing up its health benefits and being more and more recognised as a superfood. There have been over 9000 scientific studies published on the health benefits of turmeric. Making turmeric arguably the most nutritional supplement in natural health.

Compounds in turmeric that have medicinal properties are called curcuminoids. [2] One of these main compounds is curcumin. It is now well recognized as the active ingredient in turmeric that gives its powerful anti-inflammatory and potent antioxidant properties.

Turmeric Health Benefits

Let’s sit back and count the blessings that turmeric can bring to our health!

turmeric and inflammation

Turmeric as a Natural Potent Inflammation Fighter

Curcumin, the main active compound in turmeric, has suppressive effects on many factors that have major roles in our body’s inflammatory responses. Turmeric’s many health benefits are derived from this potent effect. These include various types of cells in the inflammatory process and their signalling mechanisms. [3, 12]

Acute inflammation is very helpful in helping our body to fight intruders and repair damages that they cause in our body. With our increasingly fast-paced society, mounting stress, and more toxin-filled living environment, more and more people are experiencing chronic inflammation where our body’s own tissues are getting attacked. [4] Such chronic low-level inflammation contributes to many health conditions and diseases, such as Alzheimer's disease, [7] heart conditions, [8] cancer, [5] obesity, [6] and many types of age-related degenerative conditions.

Curcumin can play a key role in the prevention and treatment of chronic inflammation-related diseases. [5,9] At a high enough dosage, Its anti-inflammatory effects can be more potent and effective than commonly used anti-inflammatory medicines such as ibuprofen and aspirin, making curcumin one of the most effective anti-inflammatory compounds in the world. [10] Turmeric not only can reduce existing inflammation, but also can help our body to not produce inflammation-inducing chemicals in inflammation prevention. [11]

turmeric antioxidant

Turmeric as an Antioxidant Superhero

Oxidative stress contributes to aging and many health conditions. Oxidative stress is caused by free radicals, which are highly reactive factors without pared electrons. They can be generated in our bodies or found in toxins in our environments such as cigarette smoke and industrial chemicals. Their highly reactive nature and chemical structure lead to their reactions with important substances for our health, including proteins, DNA and fatty acids. [13]

Curcumin has been tested for two-fold effects in the oxidative process. One is the potent antioxidant effect itself that can neutralize the highly reactive nature of free radicals, thus product our body tissue from harm. [14] This is due to curcumin's actions in working with the enzymes to deactivate free radicals, controlling certain types of enzymes from entering into certain types of free radical generation processes. [16] Also, curcumin was found to possibly enhance the actions of other antioxidants in our body to work together to reduce oxidative stress. [15]

Oxidative stress, inflammation and many chronic diseases are closely linked with factors contributing to each other. [9] curcumin’s antioxidant and anti-inflammatory effects contribute to these related health conditions.

turmeric natural pain relief

Turmeric as a Natural Pain Relief

Strong medication for acute pain relief can be helpful in surgical situations. Considering their long-term side effects, natural remedies are well recognized to be more effective and safer at alleviating chronic and degenerative pain conditions. Turmeric is one of the most effective and safe chronic pain relief. [17]

Turmeric has a long history of use in painful health conditions such as arthritis and digestive pain. Recent studies have shown its potential benefit in alleviating pain even compared to pain relief medications. [18] A study supports its pain relief effect as being comparable to ibuprofen. [20] A randomized clinical trial has shown Curcumin can significantly improve symptoms of these painful conditions. [19] Curcumin’s pain relief effect has also been studied in diabetic neuropathic pain. [21]

There are many other similar studies of curcumin on various types of pain, such as wound and burn pain, post-operative pain, neuro pain, dental-related facial pain, and menstrual pain. [22,23,24,34,35,36,37]

turmeric healthy aging

Delayed Healthy Aging Effect of Turmeric

Turmeric’s potential to help us delay the aging process comes from both its beneficial anti-inflammatory and antioxidant actions, which contribute greatly to aging, [29] and its protective mechanisms in many age-related health conditions, such as heart disease, Alzheimer’s, cancer, neurodegeneration etc.

Curcumin has been proven to increase the lifespan of insects and mice. [25,26,27] Although studies have not been done on humans, with its general safety even in larger amounts of consumption, turmeric can be a great option in the attempt to slow the aging process, therefore postponing onsets of age-related diseases. [28]

Apart from the extensively studied curcumin, turmeric also contains high levels of iron, manganese, vitamin B6 and potassium, which all have beneficial effects on our health and healthy aging. [30]

turmeric immunity booster

Turmeric Effects in Infections and Immune System Support

Curcumin in Turmeric has been recognized as an immune regulator in studies in the last 20 years. It can help modulate key immune function cells and factors for optimal immune responses. It can also downregulate proinflammatory factors, reducing damage from long-term inflammation. [31] Curcumin can also enhance antibody response in the face of outside intrusions. [32]

Curcumin has also been shown to aid our body’s response to viral infections. Having been tested for clinical effects as an antiviral agent, curcumin can be considered in the management of infection symptoms. [33,38] Several of these studies were done in the hopd of finding natural Covid recovery support.

turmeric cancer treatment

Curcumin as Potential Cancer Treatment

Curcumin in turmeric has been studied to have inhibitive effects on cancer development and duplication. [39] It has demonstrated anticancer properties in various cancer cells, including pancreas, lung, ovarian, oral, stomach, colon, breast, prostate and melanoma cancer cells. [40]

Through its regulation of different factors and pathways in cancer cell generation and death, curcumin in. turmeric has shown the ability in slowing down cancer growth, promote cancer cell death and effectively reduce their rate of migration, thus preventing cancer spread. [41,42] It also shows preventive effects against certain types of cancers, such as colon cancer through reducing and repairing damages to the colon that have the potential of turning cancerous.[43]

Evidence has shown that curcumin has positive effects in all four stages of cancer progression: cancer cell formation, growth, death and migration. [44]

Another special effect of curcumin is its ability to facilitate some chemotherapy treatments, reducing cancer cells’ resistance to medication Together with its assistance in reducing inflammation and pain from chemotherapy, this suggests a synergistic effect with traditional treatment methods. [45]

turmeric brain memory learning

Turmeric Supports the Brain, Memory and Learning

A specific neuro factor called BDNF is recognized as crucial in the healthy functioning of the brain, in memory and in learning. [46] it is responsible for promoting neuro cell generation, communication and healthy lifespans. Turmeric’s positive effect in increasing brain levels o BDNF has been proven in animal studies. [47,48] Therefore turmeric has the potential to promote healthy brain function, increase neuro cell counts, enhance neuro communications and connections, and improve memory and attention span. [49] Studies showed turmeric leads to significant improvement in brain activities associated with memory. [65]

turmeric mood anxiety depression

Turmeric and Mood, Anxiety and Depression

Turmeric supplement with curcumin has been proven in a controlled trial to have similar effects as antidepressant medication. When taken together with the antidepressant medication, patients experience the greatest improvements. [50] Two other controlled trials also provided similar results. [53,54] Depression is also related to the neuro factor BDNF, with associated reduced BDNF levels. Turmeric’s ability in increasing BDNF gives confidence in its potential to help with depression. [51] Turmeric is also shown to boost “happy factors” in the brain such as serotonin and dopamine, which helps to enhance mood and deal with stress. [52] Turmeric leads to significant improvement in brain activities associated with memory [65] and can also reduce anxiety and calm the mind before sleep. [55]

turmeric headaches migraine

Can Turmeric Help with Headaches and Migraines?

A study compared 2-month treatments of curcumin, omega-3 oil and the combination of both in migraine patients and found the combination of curcumin and omega-3 oil has the best effect. [56] We still don’t fully understand the mechanism of turmeric in reducing headaches and migraine. Its potent anti-inflammatory and antioxidant effects play a major part in such situations. Turmeric has shown positive effects in high blood pressure induced, [57] depression, anxiety and stress induce, [58] and allergy-induced [59] headaches.

turmeric chronic fatigue

Turmeric’s Potential in Chronic Fatigue

There is currently no recognized cure for chronic fatigue syndrome. Turmeric has shown promising potential in this area. As one of the most debilitating symptoms of chronic fatigue syndrome is muscle pain and soreness, curcumin supplements have been studied in randomized controlled trials with positive effects in muscle discomfort, swelling, inflammation performance and damage recovery [60]

turmeric alzheimer's disease and neurodegenerative disease

Turmeric in Alzheimer’s Disease and other Neurodegenerative Conditions

Alzheimer’s disease is also linked to reduced levels of neuro factor BDNF, [61] which turmeric can help rectify. Inflammation and oxidative stress also play a critical role in the development of Alzheimer’s disease. These areas are turmeric’s well-recognized effective areas. [62] The buildup of protein plaques is a key feature of Alzheimer’s disease. Turmeric has been shown to assist in the clearance of such plaques. [63] Curcumin also has the potential for disease prevention. [64] India has a relatively low rate of Alzheimer’s disease which may be attributed to its high usage of turmeric. More recent studies have also shown substantial improvement in symptoms in Alzheimer’s patients after turmeric supplementation. [66] Other neurodegenerative conditions that can benefit from turmeric’s neuroprotective effects include dementia, Parkinson’s disease, multiple sclerosis and Huntington’s disease. [67]

turmeric allergy asthma

Turmeric Provides Support in Allergies and Asthma

Turmeric supplementation significantly helps improve airway obstruction in asthma patients in a study. [68] Randomized controlled studies also show turmeric supplementation had significant therapeutic effects for people with allergies, improving airflow and alleviating congestion and sneezing. [69] Similar effects were also tested in food allergies. [70] This evidence suggests turmeric’s potential as a complementary treatment for allergies and asthma. [71]

turmeric thyroid function

Thyroid Functions and the Help of Turmeric

Above or below normal levels of thyroid functions are associated with digestive inflammation, stomach discomfort, gut bacterial overgrowth and high blood pressure. Turmeric has potent effects in all the above areas. [72,73] Turmeric’s strong antioxidant activity also plays an important role in thyroid protection, regulation and balance by reducing oxidative stress. [74,75,76]

turmeric healthy heart

Turmeric can Promote Heart Health

Curcumin extract from turmeric was also found to improve heart health in healthy adults. [79,80] Apart from turmeric’s anti-inflammatory and antioxidant effects, which play critical roles in the development of heart disease, the plant was also found to protect us from heart disease and even reverse disease progression through stabilizing pathways that are suppressed in heart disease. [77,78] Another valuable benefit of curcumin in heart health is its ability to support and enhance the integrity of the blood vessel lining, which is responsible for blood pressure regulation and a major factor in heart disease. [83,84]

Oral turmeric has been found equivalent to aerobic exercise in promoting blood vessel integrity in older women and equivalent to drugs to prevent heart attacks in type II diabetes patients. [81,85] A 65% reduced risk of heart attack was also demonstrated in people who took high doses of curcumin supplements after heart bypass surgery. [82]

turmeric blood sugar level diabetes

Turmeric’s Support in Healthy Blood Sugar Levels

Numerous animal studies have proven turmeric’s effects in significantly decreasing blood sugar levels, [86] helping lower blood insulin levels, [87] and improving insulin resistance and blood sugar control. [88] Curcumin in turmeric was discovered to be 400 times more potent than a common diabetes drug in modulating one of the major type 2 diabetes therapeutic targets. [90]

One study in 240 adults with early symptoms of type 2 diabetes found that 9 months of turmeric supplementation reduced the patients’ risks of eventually developing the disease. [89]

Turmeric supplementation can also reduce diabetic neuropathic pain, which is one of the serious symptoms of the disease with debilitating muscle weakness and blindness. [91] Turmeric may also protect the kidneys of type 2 diabetes patients from damage. [92]

turmeric cholesterol

Turmeric Leading to Lowered Cholesterol Levels

Randomized controlled trials found that turmeric has the potential to assist in the management of cholesterol levels and can be considered a synergistic remedy to conventional drugs. [93] Turmeric and curcumin were found to significantly reduce “bad” cholesterol levels and increase “good: cholesterol levels in our body. [94,96,97] Even low-dose supplementation has been found effective in reducing cholesterol levels and LDL levels. [95] Turmeric also led to a 78.9% improvement in liver fact content in a randomized controlled trial. [97]

turmeric arthritis osteoarthritis rheumatic arthritis

Osteoarthritis and Rheumatic Arthritis Patients Benefit from Turmeric Supplements

Turmeric supplements’ value in arthritis lies in their potent anti-inflammatory effects, as different types of arthritis involve inflammation in the joints. Curcumin in turmeric demonstrated superior effectiveness than an anti-inflammatory drug in the management of Rheumatic arthritis. [98] Even at low doses, turmeric was found to significantly improve patient outcomes. [102]

Great improvements in symptoms such as pain and stiffness were also observed in osteoarthritis patients taking turmeric supplements. [19,99] Turmeric and its curcumin have been extensively studied as a potential long-term treatment for people with osteoarthritis, due to its potent effects and safety. [100] Animal studies also provided evidence for turmeric’s potential in significantly slowing the progression of osteoarthritis. [101]

turmeric muscle recovery

Turmeric Assisting Muscle Recovery

Turmeric supplements have been found to improve muscle pain and tenderness, reduce muscle damage, lower inflammation, and increase antioxidant activity after exercise. [103] Other studies have also revealed similar results showing curcumin supplementation before and after exercise can reduce muscle damage to a certain degree and facilitate recovery. [104] Animal studies also agreed with these findings with turmeric supplements positively affecting exercise performance and recovery by reducing damage and inflammation. [105]

turmeric digestion gut health

Turmeric Aiding Digestion

Turmeric was traditionally added to curry powder not only due to its interesting addition to the taste of food but also due to its traditional medicinal property in aiding digestion of the food that curry normally went together with.

Turmeric’s beneficial effect on digestion is gaining more and more attention in the scientific field with studies trying to understand its mechanism of action. The main recognized benefits were mainly based on its anti-inflammatory soothing effects on the digestive tract and ability to promote gut lining integrity, both critical factors of healthy digestion. [106] turmeric has been found effective in helping with digestive symptoms including bloating, ulcers, and inflammations.

turmeric weight loss and obesity

Turmeric Helps with Weight Loss and Obesity

As the brain-derived neurotrophic factor (BDNF) has a major role in our brains’ regulation of eating, drinking and body weight, turmeric’s effects in increasing BDNF factor levels contribute to the brain’s healthy regulation of our body weight and eating habits. [46]

Studies have proven that turmeric supplements can significantly decrease body mass index (BMI), weight, and waist circumference. Curcumin in turmeric was concluded to have great potential in the management of obesity, which affects nearly 20% of all people. [107] Curcumin supplementation also showed excellent results in enhancing weight loss, increasing body fat reduction, reducing waistline and hip circumference, and BMI. [108]

turmeric liver health detox

Turmeric in Liver Function and Detox

Curcumin in turmeric was found to assist our liver in the process of getting rid of toxins, including mercury, [109] other heavy metals, [110] carcinogens such as carbon tetrachloride [111], and alcohol. [112]

Its effects in preventing oxidative degradation of fats also help to protect the integrity of our liver, therefore protecting, preventing and even treating liver disease. [113] Turmeric supplements have shown therapeutic potential in the treatment of several fatty liver-related conditions, including steatohepatitis and liver cirrhosis. [114,115.116]

turmeric IBS IBD colitis crohn's disease  irritable bowel syndrome

Turmeric’s Potential in IBS, IBD, Colitis and Crohn’s Disease

Turmeric’s benefits in Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) are well studied. A randomized controlled study of 700 IBS patients showed significant improvement in IBS prevalence, reduction in abdominal pain and discomfort and improvement in remission rate after treatment when patients were taking turmeric supplements. [117] Many studies also provided evidence for symptom relief with turmeric supplementation. [118,119]

A study shows that in the condition of colitis, patients who took high doses of curcumin together with prescribed medication had better outcomes staying in remission of the disease for longer periods of time. [120]

Turmeric has also been found to assist in other digestive tract conditions such as Crohn’s disease [122] and digestive symptoms such as constipation and diarrhea. [121]

turmeric prostate support men's health candida overgrowth

Turmeric’s Potential Help in Prostate Symptoms

Some studies have found turmeric supplements containing curcumin have beneficial effects on prostate markers, urinary comfort, frequency and urgency, and overall quality of life of older males. [123]

Turmeric Against Candida Overgrowth

Together with its antibacterial, antiviral, anti-inflammatory, and antioxidant functions, turmeric was more recently studied for its antifungal actions. Several studies confirmed its potential in reducing candida overgrowth [124,125] and fungal infections. [126]

turmeric skin acne oral health

Turmeric in Skin Health and Acne

Due to turmeric’s antimicrobial, anti-inflammatory and antioxidant actions, it can potential be an effective treatment for skin diseases such as acne, eczema, photoaging and psoriasis. [127] turmeric can assist skin integrity and glow, [128] speed up wound healing [129] and clear up flares such as scabies. [130]

Oral Health and Turmeric

Again due to its antimicrobial, anti-inflammatory and antioxidant actions, turmeric has been found helpful in dental conditions and oral cancers. [2] It is often found in natural mouthwash to help promote oral hygiene.

Turmeric Spice vs Supplementation and Their Absorption

turmeric supplements

One important thing to note about all the extensive research is that almost all of the research was not done based on subjects eating more curry or taking the natural form of turmeric. A higher-strength target curcumin extract of turmeric was most commonly used in these studies.

On its own as a spice turmeric has about 3% curcumin. The curcumin in turmeric is very also poorly absorbed adding to the difficulty in getting its full benefit by ingesting the spice. Having a curry dish once a month is unlikely to bring the full health benefits of turmeric and curcumin.

In order to get the potential benefits of curcumin shown in extensive research, supplements are the best option. Black pepper is well recognized to enhance curcumin’s absorption and bioavailability. Choosing a high-strength curcumin extract with the combination of black pepper can provide the best possible health benefits of turmeric and its curcumin. When a curcumin-targeted turmeric extract is combined with black pepper, the piperine in black pepper can increase curcumin’s bioavailability by an incredible 2000%. [131]

Gold Health Turmeric XTR 28,000

Gold Health high potency turmeric supplement

Gold Health Turmeric XTR 28,000 is a carefully designed formulation that has the perfect combination of curcumin and black pepper.

A high-potency turmeric exact was specifically selected to provide 95% curcumin. This is equivalent to the curcumin in 28,000mg of turmeric herb in its natural form.

This high-potency curcumin extract was then combined with black pepper to potentially increase curcumin’s bioavailability up to 20 times.

Other synergistic herbs were carefully chosen and added to the formulation to assist curcumin’s wide reached health benefits. These include:

• Ginger – the gingerol in ginger is a compound similar to piperine in black pepper. It not only has its own anti-inflammatory effects synergistic to that of turmeric but also helps further improve the bioavailability of curcumin

• Boswellia Serrata is a traditional Indian herb used in Ayurvedic medicine with similar health benefits as turmeric. Evidence has indicated its effects in similar health conditions such as osteo and rheumatoid arthritis, IBS, IBD, asthma, etc.

• Aloe Vera is also an Ayurvedic herb well recognized for its soothing and healing effects in synergy with turmeric’s anti-inflammatory actions.


1.            Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

2.            Role of curcumin in systemic and oral health: An overview

3.            Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

4.            Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

5.            Traditional Uses, Therapeutic Effects and Recent Advances of Curcumin: A Mini-Review

6.            Inflammatory links between obesity and metabolic disease

7.            Inflammation as a central mechanism in Alzheimer's disease

8.            Inflammation and Cardiovascular Diseases: The Most Recent Findings

9.            Curcumin, inflammation, and chronic diseases: how are they linked?

10.         Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation

11.         Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research

12.         Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers

13.         Oxidative stress

14.         Antioxidant and anti-inflammatory properties of curcumin

15.         Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

16.         Curcumin: A Review of Its’ Effects on Human Health

17.         Natural anti-inflammatory agents for pain relief

18.         Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

19.         The Effect of Nanocurcumin in Improvement of Knee Osteoarthritis: A Randomized Clinical Trial

20.         Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis

21.         Effect of curcumin on diabetic peripheral neuropathic pain: possible involvement of opioid system

22.         Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: a systematic review

23.         The effect of curcumin ointment on knee pain in older adults with osteoarthritis: a randomized placebo trial

24.         Curcumin Alleviates Lumbar Radiculopathy by Reducing Neuroinflammation, Oxidative Stress and Nociceptive Factors

25.         Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster

26.         The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice

27.         Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila

28.         Curcumin, inflammation, ageing and age-related diseases

29.         Oxidative stress, aging, and diseases

30.         Turmeric, the Golden Spice

31.         "Spicing up" of the immune system by curcumin

32.         Dietary curcumin enhances antibody response

33.         Curcumin (a constituent of turmeric): New treatment option against COVID‐19

34.         Curcumin: a novel therapeutic for burn pain and wound healing

35.         Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study

36.         Evaluation of antihyperalgesic effect of curcumin on formalin-induced orofacial pain in rat

37.         Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple-blind, placebo-controlled clinical trial

38.         Promising role of curcumin against viral diseases emphasizing COVID-19 management: A review on the mechanistic insights with reference to host-pathogen interaction and immunomodulation

39.         Curcumin and Cancer

40.         Potential Anticancer Properties and Mechanisms of Action of Curcumin

41.         Curcumin inhibits angiogenesis in endothelial cells using downregulation of the PI3K/Akt signaling pathway

42.         Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

43.         Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia

44.         Anticancer potential of curcumin: preclinical and clinical studies

45.         Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression

46.         BDNF gene

47.         Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats

48.         Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial

49.         Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF

50.         Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial

51.         Potentials of Curcumin as an Antidepressant

52.         Curcumin in Depression: Potential Mechanisms of Action and Current Evidence—A Narrative Review

53.         Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder

54.         Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study

55.         A Novel Potent Sleep-Promoting Effect of Turmeric: Turmeric Increases Non-Rapid Eye Movement Sleep in Mice Via Histamine H1 Receptor Blockade

56.         The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms

57.         Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study

58.         Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study

59.         Immunomodulatory effects of curcumin in allergy

60.         Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS)

61.         Decreased Serum Brain-Derived Neurotrophic Factor (BDNF) Levels in Patients with Alzheimer’s Disease (AD): A Systematic Review and Meta-Analysis

62.         Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

63.         Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients

64.         REVIEW: Curcumin and Alzheimer's Disease

65.         Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial

66.         Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia

67.         Curcumin and neurodegenerative diseases: a perspective

68.         Evaluation of Efficacy of Curcumin as an Add-on therapy in Patients of Bronchial Asthma

69.         Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis

70.         Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper T cells (Th1/Th2) balance in a mouse model of food allergy

71.         Curcumin ameliorates asthmatic airway inflammation by activating nuclear factor-E2-related factor 2/haem oxygenase (HO)-1 signalling pathway

72.         Link between hypothyroidism and small intestinal bacterial overgrowth

73.         Hypertension in Thyroid Disorders

74.         Oxidative stress in hypothyroid patients and the role of antioxidant supplementation

75.         Possible protective effect of curcumin on the thyroid gland changes induced by sodium fluoride in albino rats: light and electron microscopic study

76.         Curcumin mitigates lithium-induced thyroid dysfunction by modulating antioxidant status, apoptosis and inflammatory cytokines

77.         Curcumin as a potential protective compound against cardiac diseases

78.         Curcumin, the golden spice in treating cardiovascular diseases

79.         Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

80.         Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study

81.         Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women

82.         Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting

83.         Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress

84.         Curcumin and Endothelial Function: Evidence and Mechanisms of Protective Effects

85.         Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study

86.         Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats

87.         Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity

88.         Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

89.         Curcumin Extract for Prevention of Type 2 Diabetes

90.         Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells

91.         Effect of curcumin on diabetic peripheral neuropathic pain: possible involvement of opioid system

92.         Effect of curcumin on rats/mice with diabetic nephropathy: a systematic review and Meta-analysis of randomized controlled trials

93.         Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials

94.         A Systematic Review and Meta-analysis of Randomized Controlled Trials on the Effects of Turmeric and Curcuminoids on Blood Lipids in Adults with Metabolic Diseases

95.         The effect of curcumin on lipid level in patients with acute coronary syndrome

96.         Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers

97.         Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial

98.         A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis

99.         Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis

100.      A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis

101.      Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model

102.      A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study

103.      Influence of curcumin on performance and post-exercise recovery

104.      Curcumin and Piperine Supplementation and Recovery Following Exercise Induced Muscle Damage: A Randomized Controlled Trial

105.      Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage

106.      Efficacy and safety of Ayurvedic herbs in diarrhoea-predominant irritable bowel syndrome: A randomised controlled crossover trial

107.      The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

108.      Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study

109.      Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury

110.      Protective effect of curcumin against heavy metals-induced liver damage

111.      Effect of turmeric on xenobiotic metabolising enzymes

112.      Curcumin-galactomannosides mitigate alcohol-induced liver damage by inhibiting oxidative stress, hepatic inflammation, and enhance bioavailability on TLR4/MMP events compared to curcumin

113.      Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation

114.      New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans

115.      Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial

116.      Pharmacological actions of curcumin in liver diseases or damage

117.      Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study

118.      Efficacy of turmeric in the treatment of digestive disorders: a systematic review and meta-analysis protocol

119.      A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome (IBS)

120.      Curcumin for maintenance of remission in ulcerative colitis

121.      Effect of dietary turmeric on breath hydrogen

122.      Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases

123.      Curcumin for the Treatment of Prostate Diseases: A Systematic Review of Controlled Clinical Trials

124.      Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans

125.      Curcumin targets cell wall integrity via calcineurin-mediated signaling in Candida albicans

126.      Antifungal compounds from turmeric and nutmeg with activity against plant pathogens

127.      Curcumin: a novel treatment for skin-related disorders

128.      Herbal Treatment for Dermatologic Disorders

129.      Curcumin as a wound healing agent

130.      The use and efficacy of Azadirachta indica ADR ('Neem') and Curcuma longa ('Turmeric') in scabies. A pilot study.

131.      Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers